DTComPair - Comparison of Binary Diagnostic Tests in a Paired Study Design
Comparison of the accuracy of two binary diagnostic tests in a "paired" study design, i.e. when each test is applied to each subject in the study.
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clinical-epidemiologycomparative-analysisdiagnosisdiagnostic-accuracy-studiesdiagnostic-likelihood-ratiodiagnostic-testsmedicinepredictive-valuesensitivityspecificity
4.90 score 3 stars 53 scripts 503 downloads
tipmap - Tipping Point Analysis for Bayesian Dynamic Borrowing
Tipping point analysis for clinical trials that employ Bayesian dynamic borrowing via robust meta-analytic predictive (MAP) priors. Further functions facilitate expert elicitation of a primary weight of the informative component of the robust MAP prior and computation of operating characteristics. Intended use is the planning, analysis and interpretation of extrapolation studies in pediatric drug development, but applicability is generally wider.
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bayesian-borrowingbayesian-methodsclinical-trialevidence-synthesisextrapolationpediatricspharmaceutical-developmentprior-elicitationtipping-pointweighting
4.60 score 2 stars 10 scripts 410 downloads
BPrinStratTTE - Causal Effects in Principal Strata Defined by Antidrug Antibodies
Bayesian models to estimate causal effects of biological treatments on time-to-event endpoints in clinical trials with principal strata defined by the occurrence of antidrug antibodies. The methodology is based on Frangakis and Rubin (2002) <doi:10.1111/j.0006-341x.2002.00021.x> and Imbens and Rubin (1997) <doi:10.1214/aos/1034276631>, and here adapted to a specific time-to-event setting.
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bayesian-methodscausal-inferenceclinical-trialestimandmcmc-methodspharmaceutical-developmentprincipal-stratificationsimulationstantime-to-eventonetbbcpp
2.70 score 363 downloads